A Vision of Future Gene Therapy: Non-Viral Nanovectors

Recent developments in research have highlighted the potential of non-viral nanoparticles as vectors in gene therapy. Gene therapy typically refers to the use of nucleic acids, such as plasmids and siRNA, to genetically modify patient’s cells.1 Traditionally, viral vectors have been pursued as gene delivery vehicles, but a variety of risks and problems associated with them have limited their large-scale use clinically.