Size Comparison: Tentacle-Based Ligands Versus Common Biology
Anion-exchange chromatography (AEX) is based on coulombic interactions between biologics and the purification media. Different biologics, such as plasmid DNA, mRNA, viral vectors, and antibodies, have different dimensions, charge densities, and charge distributions. These factors together affect anion-exchange chromatography media selectivity.
Compared to conventional small molecule-based ligands, Purilogics tentacle format allows for more refined adjustment of tentacle length, tentacle composition, and ligand density. Using our Purexa™ NAEX Plus, we can leverage this ability to fine tune your custom chromatographic media to retain the high speed and capacity associated with AEX and reap the benefits of increased selectivity toward your target biologic.
If you are interested in trying our chromatography platform, please contact us at info@purilogics.com. We look forward to adding simplicity to your purifications!
