Purexa™ Membranes Vs. Magnetic Beads — More Than Faster Speed
A key focus of Purilogics is to emphasize the drastic decrease in processing time when using our membranes for biologics purification. Additionally, it is essential to note that our rapid residence times are not the only advantage of our chromatography products. The Purexa™ product line has several advantages when compared to magnetic bead chromatography products. In this post, we will be comparing Purilogics’ Purexa™ AHT, a multi-well plate utilizing our patented and proprietary Purexa™ PrA protein A membrane technology, to magnetic bead purification.
Advantages Purexa™ AHT vs. Magnetic Bead purification
Recovery and Purity: Magnetic beads are generally an effective means for purification due to their high recovery and purity characteristics, but also can pose challenges to workflow. Purexa™ AHT has the capacity for both high recovery and purity, like magnetic bead products, but also solves these workflow challenges.
Elution Volume: Usually, magnetic bead products require a high elution volume for antibody recovery. Conversely, Purexa™ AHT achieves a high antibody recovery with a very low elution volume. Thus, one can obtain highly concentrated solution when applying this membrane technology.
Time Use: As a direct effect of the Purexa™ AHT membrane’s rapid flow rate, processing 24-96 different antibodies can be completed in minutes. Conversely, leading magnetic bead products often require a few hours to purify only 2 antibodies.
Hands-On Requirement and Bead Aggregation: Magnetic bead chromatography technology requires both hands-on incubation periods and careful monitoring to resolve issues of bead aggregation. Thus, not only do these products require hours to purify a target molecule, but also this time frame demands careful hands-on management. Purexa™ AHT provides a solution to this challenge. Without any incubation periods or threats of bead aggregation, our membranes are rapid and easy to use.
Productivity/Cost: When it comes to productivity, Purexa™ AHT is a high-performance product at an affordable cost. If you are interested in detail concerning the cost of our product compared to leading magnetic bead products, please contact us!