Higher Productivity with Purexa™ Membrane Chromatography Technology
Purexa™ membranes enable purification through a convection-dominated process, thanks to their straight-through pore design. This allows for shorter residence times and higher flow rates, especially beneficial for large biologics like mRNA and plasmid DNA. With pore sizes ranging from 100 nanometers to a few micrometers, membranes offer significantly higher binding capacity compared to traditional resins.
Unlike resin columns, which require long residence times and complex setups, Purexa™ membranes streamline the purification process. They support rapid changeover, consistent performance, and easier setup and teardown — reducing production stress and improving throughput across capture and polishing steps.
Purexa™ products allow for rapid cycle times, high binding capacity, and consistent performance
Purexa™ membranes can produce faster flow rates with no incubation periods, all with easier set up and tear down, with consistency of production and longevity of results when compared to resins. This solution performs while it reduces production stressors and concerns
Higher Performance at Higher Speeds
Running with a 800 nt mRNA sample, Purexa™ OdT has more than twice the dynamic bonding capacity (DBC) while operating at 20x the flowrate compared to resins.
Purification can be completed in a matter of minutes, rather than hours.
Purexa™ MQ is a multimodal anion-exchange membrane. To determine the impact of flow rate on the binding capacity of Purexa™ MQ, we tested the DBC of the membrane using salmon sperm DNA (120,000 – 300,000 Dalton) and Bovine Serum Albumin (BSA; 60,000 Dalton) at 10 Membrane Volumes per minute (MV/min) and 50 MV/min. Results of this experiment can be noted in Figure 1: Purexa™ MQ DBC vs Flow Rate. Read More on Flow Rate & Binding Capacity here.
Recent Purexa™ Case Studies
Purexa™ Membrane Form Factors
Purilogics offers a broad portfolio of Purexa™ membrane series products in various form factors. This linear scalability provides optionality to reach precise yield targets.
Custom Membrane Development
Due to large pore structure, membranes are well-suited for large molecule purification, particularly for gene & cell therapy products. Our expert team offers specialized surface modifications, mixed-mode ligand development, as well as customized ligand and enzyme immobilizations. We can tailor modifications on membrane surfaces with various pore sizes and achieve specific ligand densities. Let us help with your membrane needs.